2015 International Achievement Award

The Society annually presents an award to an outstanding individual in recognition of their contributions and achievements in the resolution of public environmental concerns. There are no specific criteria, no age limitations, however, international scientific developments in toxicology are of special interest.  

THE INTERNATIONAL SOCIETY OF REGULATORY
TOXICOLOGY AND PHARMACOLOGY
PRESENTS
THE 2015 INTERNATIONAL
ACHIEVEMENT AWARD TO


JAMES S. BUS. Ph.D., DABT, Fellow ATS

IN RECOGNITION
OF OUTSTANDING CONTRIBUTIONS
AND LEADERSHIP IN ADVANCING
REGULATORY SCIENCE AND POLICY
IN TOXICOLOGY EARNING THE ESTEEM,
RENOWN AND ADMIRATION OF HIS PEERS


December 2, 2015 

CLICK HERE TO VIEW HIS TALK
The Heart of Toxicology: "The Dose Makes the Poison
"

James Bus, Ph.D., DABT, Fellow ATS
Senior Managing Scientist
Exponent

Professional Profile
 
Dr. James Bus is a Senior Managing Scientist in Exponent’s Health Science Center for Toxicology and Mechanistic Biology.  Dr. Bus has over 35 years of toxicology experience focused on research and evidence-based literature analyses informing potential health risks associated with chemical and pesticide exposures.  He offers chemical specific and strategic toxicology expertise addressing development, stewardship, and regulatory needs to individual industry clients and business consortia and government and non-governmental agencies.  Dr. Bus provides expertise in design, implementation, and interpretation of toxicity tests and mode of action and dose response/exposure evaluations furthering translation of toxicology findings to risk assessment.  His expertise includes target-organ and endpoint-specific modes of action, and specific toxicity of chemicals including chlorinated organics, ethylene glycol and glycol ethers, aromatic derivatives benzene, styrene, aniline and others, and pesticides such as 2,4-D.  His research interests include toxicokinetic mechanisms mediating dose-dependent expression of chemical toxicity.  He has over 120 research and review publications and has received both the Achievement Award and Founder’s Award from the Society of Toxicology in recognition of his research and leadership in toxicology. 

Dr. Bus’ experience includes over 23 years as a consulting toxicologist in the Toxicology and Environmental Research and Consulting unit of The Dow Chemical Company.  He previously held positions at the Upjohn Company, the Chemical Industry Institute of Toxicology, and as Assistant Professor of Toxicology at the University of Cincinnati.  Across all of these positions he focused on providing consulting and research expertise in support of health risk evaluations of environmental and industrial chemicals and pesticide and pharmaceutical products. 
 
Dr. Bus has served as President of the Society of Toxicology, the American Board of
Toxicology, and the Academy of Toxicological Sciences, and as a Director of the International Union of Toxicology.  He has served on various toxicology-related advisory Boards and Panels including:  ILSI-HESI and ILSI Research Foundation; the American Chemical Council LongRange Research Strategic Science Team; both EPA ORD Board of Scientific Counselors and Chartered Science Advisory Board; the National Academy of Sciences Board on Environmental Studies and Toxicology; the National Institutes of Environmental Health Sciences/National
Toxicology Program Board of Scientific Counselors (Technical Reviews Subcommittee); the FDA National Center for Toxicology Research Science Advisory Board; and Board of Directors of the Hamner Institutes. In addition, Dr. Bus served on the Chemical Substances (TLV) Committee of the American Conference of Governmental and Industrial Hygienists, the Program Committee of the Toxicology Forum, and advisory boards of the University of Michigan and Purdue University.  He is an Adjunct Professor in the Department of Pharmacology and Toxicology at Michigan State University.
  
Academic Credentials and Professional Honors
 
Ph.D., Pharmacology, Michigan State University, 1975
B.S., Medicinal Chemistry, University of Michigan, 1971
 
Toxicology Forum George H. Scott Memorial Award, 2013: Award honors an individual in the field of toxicology who has demonstrated an outstanding role in developing and applying the science of toxicology.
 
Society of Toxicology Founders Award, 2010:  Granted for “demonstration of outstanding leadership in fostering the role of toxicological sciences in safety decision-making through development and/or application of state-of-art approaches that elucidate, with a high degree of confidence, the distinctions for humans between safe and unsafe levels of exposures to chemical and physical agents.”
 
The Dow Chemical Company Responsible Care Award, 2009:  Awarded for “Implementation of the 2,4-D Extended One Generation Reproduction Study.”  This study represented the first successful conduct of this protocol, and provided information (reproduction, developmental neuro- and immunotoxicity, endocrine) key to the successful re-registration of 2,4-D.  In addition, this study established an important precedent for application of the “Kineticallyderived Maximum Dose” concept for rational dose selection in animal toxicity studies, and avoiding use of traditional Maximum Tolerated Dose approaches in a study design that might otherwise result in false positive findings.
 
Michigan State University, Department of Pharmacology and Toxicology, 2001: KE Moore Distinguished Alumnus Award.
 
Robert A. Scala Award, 1999:  Granted by the Environmental and Occupational Health Sciences Institute, Rutgers University, for outstanding contributions to the science of toxicology by an industry toxicologist.
 
Society of Toxicology Achievement Award, 1987:  Granted for outstanding contributions to the science of toxicology for an investigator under the age of 35.  
 
Licenses and Certifications
 
American Board of Toxicology, 1980; Recertified, 1985, 1990, 1995, 2000, 2005, 2010 Fellow, Academy of Toxicological Sciences, 2006–present; recertified 2013. 


 

PAST INTERNATIONAL ACHIEVEMENT AWARD RECIPIENTS

  • (2014) Jay I. Goodman, Ph.D.

  • (2013) John Fawell, Ph.D.

  • (2012) Michael L. Gargas, Ph.D.

  • (2011) Michael G. Bird, Ph.D., FRSC

  • (2010) Gio Batta Gori, Ph.D.

  • (2009) Michael Dourson, Ph.D., DABT, ATS

  • (2008) Mildred S. Christian, Ph.D., Fellow, ATS

  • (2007) Bernard A. Schwetz, D.V.M., Ph.D. 

  • (2006) Elizabeth I. Anderson, Ph.D.

  • (2005) Jerome H. Heckman, Esq.

  • (2004) Lester M. Crawford, M.D.

  • (2003) Curtis D. Klaassen, Ph.D.

  • (2002) Donald Hughes, Ph.D.

  • (2001) Joseph F. Borzelleca, Ph.D

  • (1999) Dr. Alan Rulis, Director, Office of Premarket Approval (OPA)

  • (1998) Dr. Roger O. McClellan, President, CIIT, Research Triangle Park, NC

  • (1997) Dr. Ian C. Munro, Principal, FRCPath

  • (1996) Dr. John Higginson, Retired Professor of Medicine, Georgetown University

  • (1995) Robert C. Barnard, Esq., Cleary, Gottlieb, Steen & Hamilton

  • (1994) Dr. Philip Abelson, Science Magazine, Washington, DC

  • (1993) Dr. C. Jelleff Carr, Managing Editor of RTP, Columbia, MD

  • (1991) Dr. John P. Frawley, Health & Environment International, Ltd., Wilmington, DE

  • (1990) Dr. John Doull, University of Kansas Medical Center, Kansas City, KS

  • (1989) Dr. Frederick Coulston, Coulston Foundation, Alamogordo, NM

  • (1988) Dr. Robert A. Neal, Retiring President of CIIT, Research Triangle Park, NC

  • (1987) Dr. Gaston A. Vettorazzi, Geneva, Switzerland and Dr. Frank C. Lu, Miami, FL, WHO

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