2015 International Achievement Award
The Society annually presents an award to an outstanding
individual in recognition of their contributions and achievements in the resolution of
public environmental concerns. There are no specific criteria, no age limitations,
however, international scientific developments in toxicology are of special interest.
SOCIETY OF REGULATORY
TOXICOLOGY AND PHARMACOLOGY
THE 2015 INTERNATIONAL
ACHIEVEMENT AWARD TO
JAMES S. BUS. Ph.D., DABT, Fellow ATS
OF OUTSTANDING CONTRIBUTIONS
AND LEADERSHIP IN ADVANCING
REGULATORY SCIENCE AND POLICY
IN TOXICOLOGY EARNING THE ESTEEM,
RENOWN AND ADMIRATION OF HIS PEERS
December 2, 2015
CLICK HERE TO VIEW HIS TALK
The Heart of Toxicology:
"The Dose Makes the Poison"
James Bus, Ph.D., DABT, Fellow ATS
Senior Managing Scientist
Dr. James Bus is a Senior Managing Scientist in Exponent’s Health Science
Center for Toxicology and Mechanistic Biology. Dr. Bus has over 35
years of toxicology experience focused on research and evidence-based
literature analyses informing potential health risks associated with
chemical and pesticide exposures. He offers chemical specific and
strategic toxicology expertise addressing development, stewardship, and
regulatory needs to individual industry clients and business consortia and
government and non-governmental agencies. Dr. Bus provides expertise
in design, implementation, and interpretation of toxicity tests and mode of
action and dose response/exposure evaluations furthering translation of
toxicology findings to risk assessment. His expertise includes
target-organ and endpoint-specific modes of action, and specific toxicity of
chemicals including chlorinated organics, ethylene glycol and glycol ethers,
aromatic derivatives benzene, styrene, aniline and others, and pesticides
such as 2,4-D. His research interests include toxicokinetic mechanisms
mediating dose-dependent expression of chemical toxicity. He has over
120 research and review publications and has received both the Achievement
Award and Founder’s Award from the Society of Toxicology in recognition of
his research and leadership in toxicology.
Dr. Bus’ experience includes over 23 years as a consulting toxicologist in
the Toxicology and Environmental Research and Consulting unit of The Dow
Chemical Company. He previously held positions at the Upjohn Company,
the Chemical Industry Institute of Toxicology, and as Assistant Professor of
Toxicology at the University of Cincinnati. Across all of these
positions he focused on providing consulting and research expertise in
support of health risk evaluations of environmental and industrial chemicals
and pesticide and pharmaceutical products.
Dr. Bus has served as President of the Society of Toxicology, the American
Toxicology, and the Academy of Toxicological Sciences, and as a Director of
the International Union of Toxicology. He has served on various
toxicology-related advisory Boards and Panels including: ILSI-HESI and
ILSI Research Foundation; the American Chemical Council LongRange Research
Strategic Science Team; both EPA ORD Board of Scientific Counselors and
Chartered Science Advisory Board; the National Academy of Sciences Board on
Environmental Studies and Toxicology; the National Institutes of
Environmental Health Sciences/National
Toxicology Program Board of Scientific Counselors
(Technical Reviews Subcommittee); the FDA National Center for Toxicology
Research Science Advisory Board; and Board of Directors of the Hamner
Institutes. In addition, Dr. Bus served on the Chemical Substances (TLV)
Committee of the American Conference of Governmental and Industrial
Hygienists, the Program Committee of the Toxicology Forum, and advisory
boards of the University of Michigan and Purdue University. He is an
Adjunct Professor in the Department of Pharmacology and Toxicology at
Michigan State University.
Academic Credentials and Professional
Ph.D., Pharmacology, Michigan State University,
Medicinal Chemistry, University of Michigan, 1971
Toxicology Forum George H. Scott Memorial Award, 2013: Award honors an
individual in the field of toxicology who has demonstrated an outstanding
role in developing and applying the science of toxicology.
Society of Toxicology Founders Award, 2010: Granted for “demonstration
of outstanding leadership in fostering the role of toxicological sciences in
safety decision-making through development and/or application of
state-of-art approaches that elucidate, with a high degree of confidence,
the distinctions for humans between safe and unsafe levels of exposures to
chemical and physical agents.”
The Dow Chemical Company Responsible Care Award,
2009: Awarded for “Implementation of the 2,4-D Extended One Generation
Reproduction Study.” This study represented the first successful
conduct of this protocol, and provided information (reproduction,
developmental neuro- and immunotoxicity, endocrine) key to the successful
re-registration of 2,4-D. In addition, this study established an
important precedent for application of the “Kineticallyderived Maximum Dose”
concept for rational dose selection in animal toxicity studies, and avoiding
use of traditional Maximum Tolerated Dose approaches in a study design that
might otherwise result in false positive findings.
Michigan State University, Department of Pharmacology and Toxicology, 2001:
KE Moore Distinguished Alumnus Award.
Robert A. Scala Award, 1999: Granted by the
Environmental and Occupational Health Sciences Institute, Rutgers
University, for outstanding contributions to the science of toxicology by an
Society of Toxicology Achievement Award, 1987:
Granted for outstanding contributions to the science of toxicology for an
investigator under the age of 35.
Licenses and Certifications
American Board of Toxicology, 1980; Recertified,
1985, 1990, 1995, 2000, 2005, 2010 Fellow, Academy of Toxicological
Sciences, 2006–present; recertified 2013.
INTERNATIONAL ACHIEVEMENT AWARD RECIPIENTS
(2014) Jay I. Goodman, Ph.D.
(2013) John Fawell, Ph.D.
(2012) Michael L. Gargas, Ph.D.
Michael G. Bird, Ph.D., FRSC
Gio Batta Gori, Ph.D.
(2009) Michael Dourson,
Ph.D., DABT, ATS
Mildred S. Christian, Ph.D., Fellow, ATS
Schwetz, D.V.M., Ph.D.
(2006) Elizabeth I. Anderson,
Jerome H. Heckman, Esq.
(2004) Lester M. Crawford,
(2003) Curtis D. Klaassen,
(1999) Dr. Alan Rulis,
Director, Office of Premarket Approval (OPA)
(1998) Dr. Roger O. McClellan, President, CIIT, Research
Triangle Park, NC
(1997) Dr. Ian C. Munro, Principal, FRCPath
(1996) Dr. John Higginson, Retired Professor of Medicine,
(1995) Robert C. Barnard, Esq., Cleary, Gottlieb, Steen &
(1994) Dr. Philip Abelson, Science Magazine, Washington, DC
(1993) Dr. C. Jelleff Carr, Managing Editor of RTP, Columbia, MD
(1991) Dr. John P. Frawley, Health & Environment
International, Ltd., Wilmington, DE
(1990) Dr. John Doull, University of Kansas Medical Center, Kansas
(1989) Dr. Frederick Coulston, Coulston Foundation, Alamogordo, NM
(1988) Dr. Robert A. Neal, Retiring President of CIIT, Research
Triangle Park, NC
(1987) Dr. Gaston A. Vettorazzi, Geneva, Switzerland and Dr. Frank
C. Lu, Miami, FL, WHO
© 2015 ISRTP